Effects of aneuploidy on genome structure, expression, and interphase organization in Arabidopsis thaliana.
Aneuploidy refers to losses and/or gains of individual chromosomes from the normal chromosome set.The resulting gene dosage imbalance has a noticeable affect on the phenotype, as illustrated by aneuploid syndromes, including Down syndrome in humans, and by human solid tumor cells, which are highly aneuploid.Although the phenotypic manifestations of